Publications
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Tang, K.*, Zhou, L.*, …, Zhou, X.†, Chen, S.†. High-fidelity enhanced AsCas12a knock-in mice for efficient multiplexed gene editing, disease modeling and orthogonal immunogenetics. Nature Biomedical Engineering, 2025
This work is highlighted by: Birocchi, F. and Maus, M.V., 2025. Cas12a knockin mice expand the toolbox for in vivo and ex vivo multiplexed genome editing. Developmental Cell, 60(14), pp.1931-1933. [ Read More]
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Zhou, X.*, Cao, H.*, …, & Chen, S.†. CTLA-4 tail fusion enhances CAR-T anti-tumor immunity. Nature Immunology, 2023, 24(9): 1499-1510 [Cover Article]
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Zhou, X.*, Paul R.A.*, …, & Chen, S.†. Application of CRISPR technology in cellular immunotherapy. Immunological Reviews, 2023, 320(1): 199-216.
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Peng, L.*, Renauer, P. A.*, Ökten, A.*, Fang, Z.*, Park, J. J.*, Zhou, X.*, ... & Chen, S. (2022). Variant-specific vaccination induces systems immune responses and potent in vivo protection against SARS-CoV-2. Cell Reports Medicine, 3(5).
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Dong, M. B., Wang, G., Chow, R. D., Ye, L., Zhu, L., Dai, X., Park. J.J., Kim, H. R., Errami, Y., Guzman, C. D., Zhou, X., …, & Chen, S.†. (2019). Systematic immunotherapy target discovery using genome-scale in vivo CRISPR screens in CD8 T cells. Cell, 178(5), 1189-1204
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Zhou, X., Zhao, S., He, Y., Geng, S., Shi, Y., & Wang, B. (2019). Precise spatiotemporal interruption of regulatory T-cell–mediated CD8+ T-cell suppression leads to tumor immunity. Cancer research, 79(3), 585-597.