
Our Team
Principle Investigator

Xiaoyu (Ariel) Zhou, Ph.D.
Xiaoyu Zhou is an Assistant Professor at The Wistar Institute’s Vaccine & Immunotherapy Center, and Ellen and Ronald Caplan Cancer Center. She received her B.S. in Biology Science from China Agricultural University and her Ph.D. from Fudan University, where she trained in immunology and cancer biology. She subsequently conducted her postdoc research at Yale University , where she developed immune engineering strategies and CRISPR-based multiplexed genome editing platforms to dissect and reprogram immune regulation. Her work has led to the development of novel CAR-T cell designs and genetic tools to study immune regulations in vivo. Building on this foundation, the Zhou Lab integrates immune engineering and genome editing to study intercellular immune communication and advance next-generation immunotherapies. Her research has been recognized by multiple honors, including the NIH K99/R00 Pathway to Independence Award and the Margaret Q. Landenberger Research Award. [Read More]
Postions:
2025-present | Wistar Institute Assistant Professor, Dept. of Pathology & Laboratory Medicine, University of Pennsylvania
2025-present | Assistant Professor, Vaccine and Immunotherapy Center, The Wistar Institute, USA
2025-present | Assistant Professor, Ellen and Ronald Caplan Cancer Center, The Wistar Institute, USA
2024-2025 | Associate Research Scientist, Department of Genetics, Yale School of Medicine, USA
2019-2024 | Postdoctoral Associate, Department of Genetics, Yale School of Medicine, USA
Email: xazhou@wistar.org
Lab Members

Cole Christopher
Research Assistant

Yunfei Jiao
Postdoc

Steven Dao
Undergraduate (UPenn FERBS)

Omar Dominguez
Rotation PhD Student

Future Scientist
This could be you!

Future Scientist
This could be you!